Medical Guidelines for Bufo (5-MeO-DMT)
Medical Guidelines for Bufo (5-MeO-DMT)
Important Disclaimer:
We are not doctors or medical professionals, and we do not provide medical advice. Please consult with your physician for any medically-related questions or concerns. Below are some general guidelines based on current research, intended for educational purposes only.
Introduction:
Bufo 5-MeO-DMT, also known as the "God molecule," is a powerful psychedelic substance derived from the secretions of the Bufo Alvarius toad. Compared to other entheogens, Bufo 5-MeO-DMT is known for its intense, short-lasting experiences that can lead to profound insights and a deep sense of unity. While it has shown potential for spiritual and therapeutic breakthroughs, it is essential to approach its use with caution and awareness of potential risks.
Note about Medications & Substances:
Some of the substances, herbs, medications, and supplements listed below cannot be combined with DMT during the ceremony, but are generally safe outside of the ceremony. Others, however, must be avoided for days, weeks, or even months before and after the ceremony to ensure your safety and the integrity of your experience. Please refer to your full prep guide for detailed timing, dosage considerations, and additional instructions. Following these guidelines carefully is the best way to meet the sacament safely and reverently.
Important Disclaimer:
We are not doctors or medical professionals, and we do not provide medical advice. Please consult with your physician for any medically-related questions or concerns. Below are some general guidelines based on current research, intended for educational purposes only.
Introduction:
Bufo 5-MeO-DMT, also known as the "God molecule," is a powerful psychedelic substance derived from the secretions of the Bufo Alvarius toad. Compared to other entheogens, Bufo 5-MeO-DMT is known for its intense, short-lasting experiences that can lead to profound insights and a deep sense of unity. While it has shown potential for spiritual and therapeutic breakthroughs, it is essential to approach its use with caution and awareness of potential risks.
Note about Medications & Substances:
We are not doctors or medical professionals, and we do not provide medical advice. Please consult with your physician for any medically-related questions or concerns. Below are some general guidelines based on current research, intended for educational purposes only.
Introduction:
Bufo 5-MeO-DMT, also known as the "God molecule," is a powerful psychedelic substance derived from the secretions of the Bufo Alvarius toad. Compared to other entheogens, Bufo 5-MeO-DMT is known for its intense, short-lasting experiences that can lead to profound insights and a deep sense of unity. While it has shown potential for spiritual and therapeutic breakthroughs, it is essential to approach its use with caution and awareness of potential risks.
Note about Medications & Substances:
Some of the substances, herbs, medications, and supplements listed below cannot be combined with DMT during the ceremony, but are generally safe outside of the ceremony. Others, however, must be avoided for days, weeks, or even months before and after the ceremony to ensure your safety and the integrity of your experience. Please refer to your full prep guide for detailed timing, dosage considerations, and additional instructions. Following these guidelines carefully is the best way to meet the sacament safely and reverently.
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POSSIBLY CONTRAINDICATED MEDICATIONS, SUBSTANCES, CONDITIONS, AND HERBS
Medications That Must Be Discontinued:
Monoamine Oxidase Inhibitors (MAOIs)(Including β-carbolines and harmala alkaloids found in Ayahuasca and Syrian Rue)
These must never be combined with DMT or 5-MeO-DMT.
- Harmine, Harmaline, Tetrahydroharmine (THH)
- Ayahuasca, Syrian Rue
- Moclobemide
- Tranylcypromine
- Phenelzine
- Isocarboxazid
- Selegiline
- Methylene Blue (dye)
- Linezolid (antibiotic)
CYP2D6 Inhibitors
These medications inhibit a liver enzyme critical for DMT metabolism
and may increase risk of toxicity or prolonged effects.
- Paroxetine (Paxil)
- Bupropion (Wellbutrin)
- Quinidine
- Cinacalcet
- Fluoxetine (Prozac)
- Terbinafine
- Mirabegron
- Abiraterone
- Lorcaserin
- Amiodarone
- Cimetidine
- Escitalopram (Lexapro)
- Fluvoxamine (Luvox)
- Sertraline (Zoloft)
- Celecoxib
- Cobicistat
- Clobazam
- Labetalol
- Ritonavir
- Vemurafenib
Other Substances to Avoid:Serotonergic Medications & Supplements
Can cause serotonin overload if combined with DMT.
- SSRIs, SNRIs, TCAs, MAOIs
- Buspirone
- Lithium
- 5-HTP or other serotonin precursors
Stimulants & Amphetamines
May dangerously raise heart rate and blood pressure when combined with DMT.
- Amphetamines (Adderall, Vyvanse)
- Methamphetamine
- Cocaine
- MDMA / MDA / PMA
- Ephedrine / Pseudoephedrine
- Diet pills or pre-workouts containing stimulants
CNS Depressants & Sedatives
Risk of sedation, respiratory depression, or interference with psychological safety.
- Benzodiazepines (Xanax, Valium, Ativan, Klonopin)
- Barbiturates
- Sleep aids (Ambien, Lunesta, etc.)
- Opioids / Opiates (morphine, oxycodone, heroin, etc.)
- Alcohol
Over-the-Counter Medications
Some OTC medications contain hidden serotonergic or stimulant ingredients.
- Dextromethorphan (DXM) — cough/cold medicines
- Pseudoephedrine / Phenylephrine — decongestants
- Diphenhydramine — sleep or allergy meds (Benadryl, Tylenol PM, etc.)
Herbs & Supplements
Natural substances can still be dangerous with DMT.
- St. John’s Wort
- Kava
- Kratom
- Ephedra / Ma Huang
- Yohimbe
- Ginseng
- 5-HTP, SAM-e, Rhodiola, Maca (in excess)
- Any strong herbal stimulant
Other Psychedelics & Plant Sacraments
Do not combine DMT or 5-MeO-DMT with:
- LSD, Mescaline, Psilocybin
- 5-MeO-DMT (if using NN-DMT)
- Ketamine
- Iboga / Ibogaine
- Cannabis (especially within 24–48 hours prior)
Cautionary Medical Conditions
If you have any of the following, please consult with us and your healthcare provider.
Cardiovascular
- Arrhythmias
- Heart failure
- Coronary artery disease
- History of heart attack (myocardial infarction)
- Stroke or TIA
- Bleeding or clotting disorders
- Uncontrolled hypertension
Neurological
- Epilepsy or seizure disorders
- Traumatic brain injury
- Tumors in the central nervous system
Psychiatric
- Bipolar I disorder
- Psychosis or history of psychotic episodes
- Schizophrenia or schizoaffective disorder
- Delusional or brief psychotic disorder
- Borderline or antisocial personality disorder
- Narcissistic personality disorder
- Active substance use disorder
- Active suicidality
Other Conditions
- Severe respiratory illness
- Liver or kidney failure
- Terminal illness
- Pregnancy or nursing
These guidelines are not restrictions, but protective measures — allowing your body, mind, and spirit to meet the sacrament with clarity, reverence, and safety.
Please disclose all medications, supplements, and substances openly. Every detail helps us ensure your experience is aligned with your highest wellbeing.
POSSIBLY CONTRAINDICATED MEDICATIONS, SUBSTANCES, CONDITIONS, AND HERBS
Medications That Must Be Discontinued:
Monoamine Oxidase Inhibitors (MAOIs)(Including β-carbolines and harmala alkaloids found in Ayahuasca and Syrian Rue)
These must never be combined with DMT or 5-MeO-DMT.
- Harmine, Harmaline, Tetrahydroharmine (THH)
- Ayahuasca, Syrian Rue
- Moclobemide
- Tranylcypromine
- Phenelzine
- Isocarboxazid
- Selegiline
- Methylene Blue (dye)
- Linezolid (antibiotic)
CYP2D6 Inhibitors
These medications inhibit a liver enzyme critical for DMT metabolism
and may increase risk of toxicity or prolonged effects.
and may increase risk of toxicity or prolonged effects.
- Paroxetine (Paxil)
- Bupropion (Wellbutrin)
- Quinidine
- Cinacalcet
- Fluoxetine (Prozac)
- Terbinafine
- Mirabegron
- Abiraterone
- Lorcaserin
- Amiodarone
- Cimetidine
- Escitalopram (Lexapro)
- Fluvoxamine (Luvox)
- Sertraline (Zoloft)
- Celecoxib
- Cobicistat
- Clobazam
- Labetalol
- Ritonavir
- Vemurafenib
Other Substances to Avoid:
Serotonergic Medications & Supplements
Can cause serotonin overload if combined with DMT.
- SSRIs, SNRIs, TCAs, MAOIs
- Buspirone
- Lithium
- 5-HTP or other serotonin precursors
Stimulants & Amphetamines
May dangerously raise heart rate and blood pressure when combined with DMT.
- Amphetamines (Adderall, Vyvanse)
- Methamphetamine
- Cocaine
- MDMA / MDA / PMA
- Ephedrine / Pseudoephedrine
- Diet pills or pre-workouts containing stimulants
CNS Depressants & Sedatives
Risk of sedation, respiratory depression, or interference with psychological safety.
- Benzodiazepines (Xanax, Valium, Ativan, Klonopin)
- Barbiturates
- Sleep aids (Ambien, Lunesta, etc.)
- Opioids / Opiates (morphine, oxycodone, heroin, etc.)
- Alcohol
Over-the-Counter Medications
Some OTC medications contain hidden serotonergic or stimulant ingredients.
- Dextromethorphan (DXM) — cough/cold medicines
- Pseudoephedrine / Phenylephrine — decongestants
- Diphenhydramine — sleep or allergy meds (Benadryl, Tylenol PM, etc.)
Herbs & Supplements
Natural substances can still be dangerous with DMT.
- St. John’s Wort
- Kava
- Kratom
- Ephedra / Ma Huang
- Yohimbe
- Ginseng
- 5-HTP, SAM-e, Rhodiola, Maca (in excess)
- Any strong herbal stimulant
Other Psychedelics & Plant Sacraments
Do not combine DMT or 5-MeO-DMT with:
- LSD, Mescaline, Psilocybin
- 5-MeO-DMT (if using NN-DMT)
- Ketamine
- Iboga / Ibogaine
- Cannabis (especially within 24–48 hours prior)
Cautionary Medical Conditions
If you have any of the following, please consult with us and your healthcare provider.
Cautionary Medical Conditions
If you have any of the following, please consult with us and your healthcare provider.
Cardiovascular
- Arrhythmias
- Heart failure
- Coronary artery disease
- History of heart attack (myocardial infarction)
- Stroke or TIA
- Bleeding or clotting disorders
- Uncontrolled hypertension
Neurological
- Epilepsy or seizure disorders
- Traumatic brain injury
- Tumors in the central nervous system
Psychiatric
- Bipolar I disorder
- Psychosis or history of psychotic episodes
- Schizophrenia or schizoaffective disorder
- Delusional or brief psychotic disorder
- Borderline or antisocial personality disorder
- Narcissistic personality disorder
- Active substance use disorder
- Active suicidality
Other Conditions
- Severe respiratory illness
- Liver or kidney failure
- Terminal illness
- Pregnancy or nursing
These guidelines are not restrictions, but protective measures — allowing your body, mind, and spirit to meet the sacrament with clarity, reverence, and safety.
Please disclose all medications, supplements, and substances openly. Every detail helps us ensure your experience is aligned with your highest wellbeing.
AGAPE SANCTUARY © 2025. All rights reserved
San Diego Earth Sacrament Psychedelic Ceremonial Retreats and Earth Sacrament Psychedelic Ceremonial Retreats in Southern California.
San Diego Earth Sacrament Psychedelic Ceremonial Retreats and Earth Sacrament Psychedelic Ceremonial Retreats in Southern California.
CONTACT
Email: love@agapeayahuasca.com
Instagram: @agape.sanctuary
Email: love@agapeayahuasca.com
Instagram: @agape.sanctuary
AGAPE SANCTUARY © 2025. All rights reserved - San Diego Earth Sacrament Psychedelic Ceremonial Retreats and Earth Sacrament Psychedelic Ceremonial Retreats in Southern California.